Bioinformatics scientist sollicitatievragen


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Marshfield Clinic
Er werd een Bioinformatics Scientist gevraagd...5 juni 2018

Can you manipulate bclfastq files?

2 antwoorden

I described the pipeline I constructed.

lots of script can do bclfastq, why ask this question?

Personal Genome Diagnostics

Do you feel you would fit in a culture of rapid-change?

2 antwoorden

I hedged my bets. I said that I was fine with rapid-change as long as the goals were clearly defined each time they changed. Minder

Yes I do no I will be a good person for the position cause I'm a team player and I like meet different people Minder

Pacific Biosciences

Asking me about NGS experience, general and w/ PacBio.

1 antwoorden

Described NGS functions in previous jobs.


Have you ever encountered batch effect or any technical effect. What was the impact on your data and how do you control for these unwanted variables.

1 antwoorden

Use the ComBat function from the SVA Bioconductor package to combat batch effect


how to convert SAM to BAM files?

1 antwoorden

samtools view -Sb >

Twist Bioscience

Some coding and statistics questions, some questions about NGS pipelines.

1 antwoorden

Did you have to do a drug test?


NGS data analysis workflow/pipeline and tools

1 antwoorden

The current "best" tools for differential expression analysis, e.g. DESeq2 and EdgeR, incorporate normalization factors accounting for library size and composition. Pointedly, these tools do not "just" normalize prior to analysis, they include the normalization factors as features within the model. If you are looking to utilize a neural network, hierarchical bayesian, or other type of machine learning approach to differential expression, determining the appropriate method of normalization will be a make or break point. Minder

Intermountain Healthcare

Do you have experience in analyzing SNP's? If so, describe

1 antwoorden


JMI Laboratories

Why do you want to live in Iowa?

1 antwoorden

Never been in a place with real seasons. I'm sure I'd get sick of winters, but I have a strong belief in experiencing as many different places as possible. I think JMI laboratories is doing good work in anti-bacterial research and I want to be a part of that, the location isn't as important. Minder


Introduce a project you did before and introduce your ability of using tools in bioinformatics

1 antwoorden

I took my example of RNA-SEQ and explain the detail

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